Gene Regulation in Cancer & Development (01:694:492)
This course may be used to fulfill the elective requirements of the Biological Sciences major.
Pre- or Corequisites: 01:694:407-408 or 01:447:384-385 or 11:115:403-404 or 11:126:481
Class time: Mon. & Thurs. 10:20 - 11:40 AM
Gene Regulation in Cancer and Development is a course for advanced undergraduate students majoring in the Life Sciences. Molecular biology is an experimental science, and a major goal of this course is to explain not just what molecular biologists know, but how they know it. Thus, while covering selected topics in gene regulation, development, and cancer, we will emphasize the methods, experimental design, history, and deductive reasoning that has led to the current state of understanding of these topics.
For Spring 2021: The course will be taught “live” on-line. Although, lectures will be recorded and posted after class, attendance during the live sessions is important as students will be graded on class discussions. The PowerPoint lecture material and readings for each class will be posted on the relevant Sakai site for this course.
Syllabus (subject to revision):
|21-Jan||Steward||Course introduction & review of some fundamental concepts in molecular biology|
|25-Jan||Steward||Drosophila as a model system: genetics and development|
|28-Jan||Steward||Induction of mutations and analysis of mutant phenotypes|
|1-Feb||Steward||Genomics and micro RNAs|
|4-Feb||Steward||Control of gene expression in development: activated and repressed promoters|
|8-Feb||Steward||Prenatal diagnosis/ Inherited diseases in humans|
|18-Feb||Steward||Personal genomics II|
|22-Feb||Steward||Exam 1 (lecture and reading materials; Jan 25-Feb 18)|
|8-Mar||Edery||Circadian rhythms: overview and principles|
|11-Mar||Edery||Clock mechanisms I|
|22-Mar||Edery||Clock mechanisms II|
|25-Mar||Edery||Circadian rhythms and connection to cancer and other diseases I|
|29-Mar||Edery||No class (study day)|
|1-Apr||Edery||Exam 2 (lecture and reading materials; Feb 25-Mar 25)|
|5-Apr||Edery||Circadian rhythms and connection to cancer and other diseases II|
|8-Apr||Edery||Signaling to and from the clock|
|12-Apr||Edery||Clock, feeding, microbiome, disease|
|15-Apr||Edery||Clock, cancer, metabolism|
|May 3||Edery||Exam 3 (lecture and reading materials; April 5-29)|
Course Satisfies Learning Goals
1. Students should demonstrate an understanding of the knowledge that is needed to begin biomedical research and that is required for post-graduate exams and studies.
2. Students should demonstrate the ability to find and evaluate information about specific biological systems or problems.
Exams, Assignments, and Grading Policy
The course will be taught “live” on-line. Although, lectures will be recorded and posted after class, attendance during the live sessions is important as students will be graded on class discussions. The PowerPoint lecture material and readings for each class will be posted on the relevant Sakai site for this course. There will be three exams over the semester that will cover the material presented in class; there will not be a cumulative final exam. Each exam will count for 25% of the grade. In addition, there will be problem sets, in class quizzes, critiques, and/or other assignments that together will count for the remaining 25% of the grade. Absence from exams will be excused only in the case of serious illness or family emergency, and only when backed up by appropriate documentation. Requests for regrades must be submitted within 72 hours of return of the exam.
Because we are focusing on current topics, there is no textbook, but there will be assigned readings and literature research from the primary literature, and where appropriate, background reference material will be recommended by the instructors.
f this course is closed please contact Dr. Isaac Edery concerning special permission numbers.
The course will be taught by two faculty members from the Department of Molecular Biology and Biochemistry, Drs. Isaac Edery and Ruth Steward, plus some guest lecturers.
** All information is subject to change at the discretion of the course coordinator.