Course Descriptions

MOLECULAR BIOLOGY AND BIOCHEMISTRY (01:694:408/11:115:512)

This course is intended for Life Science majors or those with a strong background in the Biological Sciences.

This course may be used to fulfill the elective requirements of the Biological Sciences major.


Offered:  For Spring 2022 this course will be taught in person Tuesdays/Thursdays 3:50-5:10 PM in Tillet Hall Rm-254 on Livingston campus

Credits:   3

Prerequisites: Prerequisite for 01:694:408 is 01:694:407 (preferred), or 01:694:301, 11:115:301, or 11:115:403. Credit not given for both 01:694:408 and 01:146:478 or 11:126:481.

Course Description

Molecular Biology and Biochemistry 01: 694:407-408 is offered as the primary lecture courses for undergraduate students in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry 11:115:511-512 mainly serves graduate students in Graduate Programs other than Molecular Biosciences. Topics in the 408/512 course include recombinant DNA approaches, DNA replication, repair and recombination, mobile genetic elements, transcription and gene regulation, RNA processing and splicing, and translation.

Course URL: A Canvas site will be set up at the beginning of the semester

Tentative Lecture Schedule

# Day Date Topic Instructor Chapter in Watson et al 7th ed.
1 Tues. 1/18 DNA Structure This email address is being protected from spambots. You need JavaScript enabled to view it. 4: 77-92
2 Thurs 1/20 DNA Replication Proteins – Structure, Function & In-vitro activities   9: 257-278
3 Tues. 1/25 Regulation of DNA Topology - Prokaryotic and Eukaryotic   4: 93-103, 8:220-222, 2: 21-30
4 Thurs 1/27 Prokaryotic DNA Replication   9: 278-296
5 Tues.  2/1 Eukaryotic DNA Replication   9: 296-311
6 Thurs  2/3 Recombinant DNA 1   7: 147-168
 E1 Tues.  2/8 Exam I (Covers Lectures 1-6) See exam rules below    
7 Thurs  2/10 Recombinant DNA 2   7: 147-168
8 Tues.  2/15 DNA Damage & Mutability   10: 313-324
9 Thurs  2/17 DNA Repair   10: 324-338
10 Tues.  2/22 Homologous & Site-specific Recombination   11: 341-375
11 Thurs  2/24 DNA Transposition and Ig Gene Rearrangement   12: 377-420
12 Tues.  3/1 Genome Structure and Chromatin   8: 199-255
 E2 Thurs  3/3 Exam II (Covers Lectures 7-12)    
13 Tues.  3/8 Basic Mechanisms of Transcription  This email address is being protected from spambots. You need JavaScript enabled to view it. 13:429-462
14 Thurs  3/10 Transcriptional Regulation in Bacteria   18:615-635
  Tues.  3/15 Spring Break    
  Thurs  3/17 Spring Break    
15 Tues.  3/22 Transcriptional Regulation in Bacteria and Phage   18:636-652
16 Thurs  3/24 Methods in Molecular Biology and Biochemistry   7:168-190
17 Tues.  3/29 Transcriptional Regulation in Eukaryotes 1   13: 462-464, 19: 657-686
18 Thurs 3/31 Transcriptional Regulation in Eukaryotes 2   19: 687-698
 E3 Tues.  4/5 Exam III (Covers Lectures 13-18)    
19 Thurs  4/7 Post-transcriptional Control: Splicing & Polyadenylation This email address is being protected from spambots. You need JavaScript enabled to view it. 5:107-118, 14:467-506
20 Tues  4/12 Post-transcriptional Control: Splicing & Polyadenylation (cont.)   114:467-506‡
21 Thurs  4/14 Post-transcriptional Control: Splicing & Polyadenylation (cont.)   14:467-506‡
22 Tues.  4/19 RNA World, Ribozymes, RNA Splicing   14:467-506‡, 20:701-731
23 Thurs  4/21 Control of mRNA Translation, Stability, Localization   20:701-731
24 Tues.  4/26 Translation: Bacterial & Eukaryotic   15:509-544‡, 6:573-590
25 Thurs  4/28 Translation: Bacterial & Eukaryotic   15:509-544‡, 16:573-590
 E4   TBD Exam IV (Covers Lectures 19-25)    

Course Satisfies Departmental Learning Goals

1. Students should demonstrate an understanding of the knowledge that is needed to begin biomedical research and that is required for post-graduate exams and studies.

2. Students should demonstrate the ability to find and evaluate information about specific biological systems or problems.

3. Students should demonstrate the ability to design experiments and critically analyze data.

Exams, Assignments, and Grading Policy

694:408 Grades will have two components: 
1. Exams (100%): Four examinations of equal weight will be given on the indicated dates. Exam questions will consists of multiple choice, multiple answer, calculation and short answer responses. Exams will be administered in-person only. 

Students who miss an exam will have 24 hours after the exam due date to contact the coordinator to arrange a makeup. If an exam is missed because of illness, a makeup exam will be available if supporting documentation is provided from a physician. Makeup exams may occasionally also be scheduled by prior arrangement with the coordinator in case of extraordinary events. If no previous arrangement has been made or documentation provided, then a fifteen (15) point penalty will be applied. Any makeup is to take place within 72 hours of the exam due date. 

2. Extra credit for submitting online course survey to CTAAR (+0.25%).  Submit your anonymous course survey, also known as SIRS, during the last week of class and upload your receipt through Canvas to obtain extra credit. More information on how to obtain and submit the receipt will be provided when the survey opens.

115: 512 Grades will have a second component to their Exam grade:
3. Graduate students will submit a 1000-word term paper on a current topic in molecular biology. Topics will be assigned and submitted through Canvas no later than 5 PM April 23, 2022.  

All exams are closed book. All four examinations will be averaged and weighted equally in assigning final grades. In the rare case that you suspect an exam question has not been accurately graded, a request for re-grading will be considered WITHIN ONE WEEK AFTER EXAM PAPERS HAVE BEEN RETURNED. In such cases, the entire exam will be regraded so that points may be added or subtracted as appropriate.

Academic Integrity Policy: Students are expected to follow the Rutgers Academic Integrity Code. When required of graduate students, written work is also subject to this policy. Violations include: cheating, fabrication, plagiarism, denying others access to information or material, and facilitating violations of academic integrity. It is not permitted for students to share information about exam questions or answers during an assessment period, and there will be zero tolerance in cases where this occurs. Students caught cheating will get a zero for the exam and the Dean's office will be notified.

Students who are unable to take an hourly exam at the scheduled time because of compelling reasons supported by documentation, such as a note from their physician - NOT THE HEALTH CENTER - may be permitted to take a make-up examination.  Arrangements should be made with Prof. Bunting

Disability:Students with disabilities who require accommodation must follow the procedures outlined by the Office of Disability Services (https://ods.rutgers.edu)

Course Materials
Watson, J.D., et al. (2014) Molecular Biology of the Gene, 7th Ed., Pearson. (ISBN: 9780321762436)
‡Supplemental Readings will be posted on the Canvas site for the course. 

Course Closed?

 If 694:408 is closed please contact DrThis email address is being protected from spambots. You need JavaScript enabled to view it.

Faculty

Course Coordinator:

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CABM 337
phone: (732) 235-5333

Participating Faculty:

Dr. This email address is being protected from spambots. You need JavaScript enabled to view it.
Nelson Biology Labs, A-322
phone: (732) 445-1016

Student-Wellness Services:

Just In Case Web App: http://codu.co/cee05e

Access helpful mental health information and resources for yourself or a friend in a mental health crisis on your smartphone or tablet and easily contact CAPS or RUPD.

 

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(848) 932-7884 / 17 Senior Street, New Brunswick, NJ 08901/ rhscaps.rutgers.edu/

CAPS is a University mental health support service that includes counseling, alcohol and other drug assistance, and psychiatric services staffed by a team of professional within Rutgers Health services to support students’ efforts to succeed at Rutgers University. CAPS offers a variety of services that include: individual therapy, group therapy and workshops, crisis intervention, referral to specialists in the community and consultation and collaboration with campus partners. 

 

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The Office for Violence Prevention and Victim Assistance provides confidential crisis intervention, counseling and advocacy for victims of sexual and relationship violence and stalking to students, staff and faculty.  To reach staff during office hours when the university is open or to reach an advocate after hours, call 848-932-1181.

 

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(848) 445-6800 / Lucy Stone Hall, Suite A145, Livingston Campus, 54 Joyce Kilmer Avenue, Piscataway, NJ 08854 /  https://ods.rutgers.edu/

 

The Office of Disability Services works with students with a documented disability to determine the eligibility of reasonable accommodations, facilitates and coordinates those accommodations when applicable, and lastly engages with the Rutgers community at large to provide and connect students to appropriate resources.

 

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Free and confidential peer counseling and referral hotline, providing a comforting and supportive safe space.


** All information is subject to change at the discretion of the course coordinator.