Course Descriptions

MOLECULAR BIOLOGY AND BIOCHEMISTRY (01:694:408/11:115:512)

This course is intended for Life Science majors or those with a strong background in the Biological Sciences.

This course may be used to fulfill the elective requirements of the Biological Sciences major.


Offered:  For Spring 2021 this course will be taught on line in an asynchronous manner.   
Lectures will be offered through Canvas using Zoom at 10.20 a.m. on class days. Instructors will be available after class to answer students’ questions.
For asynchronous learning, lectures will additionally be recorded and posted on Canvas.  

Credits:   3

Prerequisites: Prerequisite for 01:694:408 is 01:694:407 (preferred), or 01:694:301, 11:115:301, or 11:115:403. Credit not given for both 01:694:408 and 01:146:478 or 11:126:481.

Course Description

Molecular Biology and Biochemistry 01: 694:407-408 is offered as the primary lecture courses for undergraduate students in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry 11:115:511-512 mainly serves graduate students in Graduate Programs other than Molecular Biosciences. Topics in the 408/512 course include recombinant DNA approaches, DNA replication, repair and recombination, mobile genetic elements, transcription and gene regulation, RNA processing and splicing, and translation.

Course URL: A Canvsa site will be set up at the beginning of the semester

Tentative Lecture Schedule

# Day Date Topic Instructor Chapter in Watson et al 7th ed.
1 Tues. 1/19 DNA Structure This email address is being protected from spambots. You need JavaScript enabled to view it. 4: 77-92
2 Fri. 1/22 DNA Replication Proteins – Structure, Function & In-vitro activities   9: 257-278
3 Tues. 1/26 Regulation of DNA Topology - Prokaryotic and Eukaryotic   4: 93-103, 8:220-222, 2: 21-30
4 Fri. 1/29 Prokaryotic DNA Replication   9: 278-296
5 Tues.  2/2 Eukaryotic DNA Replication   9: 296-311
6 Fri.  2/5 Recombinant DNA 1   7: 147-168
 E1 Tues.  2/9 Exam I (Covers Lectures 1-6) See exam rules below    
7 Fri.  2/12 Recombinant DNA 2   7: 147-168
8 Tues.  2/16 DNA Damage & Mutability   10: 313-324
9 Fri.  2/19 DNA Repair   10: 324-338
10 Tues.  2/23 Homologous & Site-specific Recombination   11: 341-375
11 Fri.  2/26 DNA Transposition and Ig Gene Rearrangement   12: 377-420
12 Tues.  3/2 Genome Structure and Chromatin   8: 199-255
 E2 Fri  3/5 Exam II (Covers Lectures 7-12)    
13 Tues.  3/9 Basic Mechanisms of Transcription  This email address is being protected from spambots. You need JavaScript enabled to view it. 13:429-462
14 Fri  3/12 Transcriptional Regulation in Bacteria   18:615-635
  Tues.  3/16 Spring Break    
  Fri.  3/19 Spring Break    
15 Tues.  3/23 Transcriptional Regulation in Bacteria and Phage   18:636-652
16 Fri.  3/26 Methods in Molecular Biology and Biochemistry   7:168-190
17 Tues.  3/30 Transcriptional Regulation in Eukaryotes 1   13: 462-464, 19: 657-686
18 Fri.  4/2 Transcriptional Regulation in Eukaryotes 2   19: 687-698
 E3 Tues.  4/6 Exam III (Covers Lectures 13-18)    
19 Fri.  4/9 Post-transcriptional Control: Splicing & Polyadenylation This email address is being protected from spambots. You need JavaScript enabled to view it. 5:107-118, 14:467-506
20 Tues  4/13 Post-transcriptional Control: Splicing & Polyadenylation (cont.)   114:467-506‡
21 Fri.  4/16 Post-transcriptional Control: Splicing & Polyadenylation (cont.)   14:467-506‡
22 Tues.  4/20 RNA World, Ribozymes, RNA Splicing   14:467-506‡, 20:701-731
23 Fri.  4/23 Control of mRNA Translation, Stability, Localization   20:701-731
24 Tues.  4/27 Translation: Bacterial & Eukaryotic   15:509-544‡, 6:573-590
25 Fri  4/30 Translation: Bacterial & Eukaryotic   15:509-544‡, 16:573-590
 E4   5/4  Exam IV (Covers Lectures 19-25)    

Course Satisfies Departmental Learning Goals

1. Students should demonstrate an understanding of the knowledge that is needed to begin biomedical research and that is required for post-graduate exams and studies.

2. Students should demonstrate the ability to find and evaluate information about specific biological systems or problems.

3. Students should demonstrate the ability to design experiments and critically analyze data.

Exams, Assignments, and Grading Policy

694:408 Grades will have two components: 
1. Exams (100%): Four examinations of equal weight will be given on the indicated dates. Exam questions will consists of multiple choice, multiple answer, calculation and short answer responses. Exams will be administered as a Canvas “quiz” using LockdownBrowser and will be available during an 8 hour window on the day of the exam. Instructions for how to install and test LockdownBrowser will be provided ahead of Exam 1. Exams will be designed to be completed in less than 2 hours, and additional time will not normally be available for IT issues. 

Students who miss an exam will have 24 hours after the exam due date to contact the coordinator to arrange a makeup. If an exam is missed because of illness, a makeup exam will be available if supporting documentation is provided from a physician. Makeup exams may also be scheduled by prior arrangement with the coordinator in case of extraordinary events. If no previous arrangement has been made or documentation provided, then, a fifteen (15) point penalty will be applied. Any makeup is to take place within 72 hours of the exam due date. 

2. Extra credit for submitting online course survey to CTAAR (+0.25%).  Submit your anonymous course survey, also known as SIRS, during the last week of class and upload your receipt through Canvas to obtain extra credit. More information on how to obtain and submit the receipt will be provided when the survey opens.

115: 512 Grades will have a second component to their Exam grade:
3. Term Paper (7.5% of Graduate students will submit a 1000-word term paper on a current topic in molecular biology. Topics will be assigned and submitted through Canvas.  2” tool no later than 5 PM April 23, 2021.  

All exams are closed book. All four examinations will be averaged and weighted equally in assigning final grades. In the rare case that you suspect an exam question has not been accurately graded, a request for re-grading will be considered WITHIN ONE WEEK AFTER EXAM PAPERS HAVE BEEN RETURNED. In such cases, the entire exam will be regraded so that points may be added or subtracted as appropriate.

Hourly examinations will be given at the end of each series of lectures on the indicated dates; the first three will be held during regular class hours and students will sit in assigned seats in the SERC 111 classroom or in an "overflow" room that will be announced. The fourth hourly examination will be held during the final exam period, in a room to be announced. There will be no cumulative final exam and the graded final exam will not be returned to students. 

All exams are closed book. Students are expected to follow the Rutgers Academic Integrity Code and will not be permitted to have bags, phones or papers by their seats. Students caught cheating will get a zero for the exam and the Dean's office will be notified.  All four examinations will be averaged and weighted equally in assigning final grades. In the rare case that an exam question has not been clearly graded, a request for re-grading will be considered WITHIN ONE WEEK AFTER EXAM PAPERS HAVE BEEN RETURNED. Note that the entire exam will be regraded so that points may be added or subtracted due to grading errors.

Students who are unable to take an hourly exam at the scheduled time because of compelling reasons supported by documentation, such as a note from their physician - NOT THE HEALTH CENTER - may be permitted to take a make-up examination. However, a 5 pt deduction will be made for the first make-up, 10 pts for the second and 20 pts for the third. Arrangements should be made with Prof. Brill.

5% of the final grade will be determine by in class iClicker responses

Course Materials
Watson, J.D., et al. (2014) Molecular Biology of the Gene, 7th Ed., Pearson. (ISBN: 9780321762436)
‡Supplemental Readings will be posted on the Canvas site for the course. 

Course Closed?

 If 694:408 is closed please contact DrThis email address is being protected from spambots. You need JavaScript enabled to view it.

Faculty

Course Coordinator:

This email address is being protected from spambots. You need JavaScript enabled to view it.
CABM 337
phone: (732) 235-5333

Participating Faculty:

Dr. This email address is being protected from spambots. You need JavaScript enabled to view it.
Nelson Biology Labs, A-322
phone: (732) 445-1016


** All information is subject to change at the discretion of the course coordinator.