Special Topics in Molecular Biology and Biochemistry: The Biology of Aging (01:694:421)
This course is intended for Life Science majors or those with a strong background in the Biological Sciences.
This course may be used to fulfill the elective requirements of the Biological Sciences major.
Offered: Spring 2022 M/W 3:50-5:00 PM Nelson Hall Rm A-237
Prerequisites: Genetics (01:447:380 or 01:447:384/385) and Biochemistry (01:694:301 or 01:694:407).
Course Description: This course will discuss state-of-the-art understanding of the biology of aging and longevity, considering what we know, what are particular challenges to tackling the problem, what are the controversies, what are the myths. Topics we will consider are genetics, diet, environment, chance, signaling pathways, epigenetics, late onset diseases. Format will be lecture plus reading discussions, emphasis on molecular genetics of longevity and health span.
What is aging?
Model systems in aging research
Genetics of Longevity
Longevity signaling pathways
DNA damage and maintenance
Stress responses and healthy aging
Free radical theory of aging
Metabolism and Diabetes
The aging brain
Late-onset Neurodegenerative disease
Stem Cells and regenerative biology
Course URL: All course materials will be posted on the course Sakai site
Course Satisfies Learning Goals
1. Students should demonstrate an understanding of the knowledge that is needed to begin biomedical research and that is required for post-graduate exams and studies.
2. Students should demonstrate the ability to find and evaluate information about specific biological systems or problems.
3. Students should demonstrate the ability to design experiments and critically analyze data.
Exams, Assignments, and Grading Policy:
20% Quizzes 3-4, will announce dates, one week in advance
25% Exam 1 midterm
25% Exam 2 final
20% Paper presentations
10% Class participation (hw questions, discussion—you will need to attend class!)
Course Materials: Assigned papers, weekly readings will be posted at the course Canvas site.
Faculty: Prof. Monica Driscoll
** All information is subject to change at the discretion of the course coordinator.