Prerequisites
Foundational courses in Molecular Biology and Biochemistry (01:694:407 or 01:694:395 or 01:694:301) and Genetics (01:447:380).
Course Syllabus
Spring 2025 (Subject to change)
Course Description
This course is an exploration of the cutting-edge techniques and technologies used in protein biochemistry, proteomics, and functional genomics. Students will gain a deep understanding of protein structure, purification methods, enzyme kinetics, genome editing, and the vast field of genomics. The course will cover topics such as:
- Introduction to genomics and proteomics
- Advancements in DNA sequencing technologies and their applications
- Chromatin structure and genome organization
- Single-cell analysis approaches
- Mass spectrometry in proteomics
- Protein folding and interactions
- Macromolecular assemblies and condensates
- CRISPR-based genome editing
- Next-generation sequencing technologies
- Student-led presentations on genetic diseases
For 2025: This year's course will also feature two lectures by Dr. Kevin Monahan on single-cell analysis approaches and 3D chromatin folding.
Course URL
Canvas
Course Satisfies Learning Goals
- Students will gain a comprehensive understanding of the knowledge and skills required to conduct biomedical research in proteomics and functional genomic.
- Students will develop the ability to independently research and evaluate information about specific biological systems or problems.
Exams, Assignments, and Grading Policy
- Take-home Exam I: 30%
- Take-home Exam II: 30%
- Student Presentation: 25%
- Take-home Exam III: 15%
- Class participation will also be taken into account, particularly during student presentations.
There will be no final exam. Late submissions will only be accepted if prior notice is given, and a further extension will not be granted. Late submissions without notice may result in a grade deduction based on the length of the delay, up to a maximum of 30%.
Course Materials
Instructors will supply the necessary readings. For conducting next-generation sequencing analysis, students must have access to a personal computer with a physical keyboard and an internet connection.
Course Closed?
This course is by special permission only, with priority given to MBB majors. The majority of the class will be juniors and seniors. To obtain a special permission number or to get on the waiting list if you are not an MBB major, CALL 848-445-2075. If the course is closed, please use the following link: Wait List Sign Up for Spring 2025 Courses
If you have any questions, please contact the Division of Life Sciences - Office of Undergraduate Instruction at 848-445-2075 or visit our office at Nelson Biological Laboratories B112, Busch Campus.
Faculty
Dr. Jia Fei
E-mail:
Dr. Stephen Anderson
E-mail:
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** All information is subject to change at the discretion of the course coordinator.
